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The Beckman Research Scholars Awards are made possible by the Arnold and Mabel Beckman Foundation in support of truly exceptional undergraduate students who are committed to a research-based career in Biology or Chemistry. The Beckman Scholars will complete an Honors Thesis on their research.
The Schering-Plough Corporation funds exceptional students in Biology and Chemistry who are interested in a research or medical career. Recipients of this prestigious award not only conduct Honors Thesis research at UCLA during the academic year, but participate in a special internship at Schering-Plough laboratories in the summer.
2008-2009 Schering-Plough Scholars
Ms. Shuk Wai Chan
Mentor: Dr. Shimon Weiss, Dr. Gopal Iyer
Funding: Schering-Plough Scholar
Title: In vivo protein ligation of a type II membrane protein, human transferrin receptor 2, to peptide coated quantum dots
Dr. Gopal Iyer, Shuk Chan and Dr. Shimon Weiss
Shuk W. Chan is a fourth year Biochemistry major. Shuk is working on developing a strategy that involves covalently conjugating glycine peptide-coated quantum dots to TFR2, Human transferrin receptor 2, protein which has been tagged with an acceptor sequence recognized by the bacterial enzyme Sortase A. Human transferrin receptor 2 ( TFR2) is a homologue of transferrin receptor 1, a protein that is responsible for delivering iron to cells via receptor-mediated endocytosis of diferric transferrin (Fe 2Tf). The primary function of TFR2 is assumed to be the regulation of systemic iron homeostasis. Using single molecule wide field microscopy, the labeled protein can be detected and this will eventually lead to characterizing the trafficking of the labeled TFR2-Qdot conjugate in cells.
Shuk received the Schering Plough Scholarship which allowed her to carry out research at Schering-Plough Biopharma in Palo Alto, California during the summer of 2008. She worked with her mentor John Mumm, in the oncology department. The lab has data that suggest IL-23 promotes tumor growth. Shuk took part in characterizing a subunit, p19, of interleukin-23 (IL-23). She generated data that demonstrate there are several factors involved in the inflammatory respond pathway that could activate the secretion of p19 in U937 and HL60 tumor cell lines.
Shuk would like to take this opportunity to thank Schering-Plough and URC/ CARE for providing the wonderful research opportunity. She would also like to thank Martin, Xueqing, Lingling, Jie, Jan, and especially John for the coffee/cake breaks, their support and guidance. She would also like to thank Dr. Shimon Weiss and the rest of the lab for their continued support. She wants to express her thanks to Gopal for everything.
